• Journal · 09/10 — Ostojic 2014 : fibromyalgie −38% douleur en 4 sem

The Source — the HYDROGENYX Journal

Journal · 09/10 — Ostojic 2014: fibromyalgia −38% pain in 4 weeks

Paul Fournier


The Serbian randomised trial on 22 fibro patients. Pain index −38% vs −7% placebo.

22 patients. 4 weeks. VAS pain index −38% vs −7% placebo.

Ostojic, Stojanovic et al. 2014 (Journal of Lifestyle Medicine) randomised 22 patients diagnosed with fibromyalgia (ACR 2010 criteria) into two groups: HRW (1 L/day, 7 ppm) vs visually identical still water placebo.

Primary outcome: VAS pain index (0-10 scale). Measurements at T0 and T+4 weeks. Secondary outcomes: Fibromyalgia Impact Questionnaire (FIQ), SF-36 quality of life score.

At T+4 weeks: VAS pain −38% (from 7.2 to 4.5) in the HRW group vs −7% (from 7.1 to 6.6) in placebo (p=0.002). FIQ improved by 21% vs 4%. SF-36 vitality +28% vs +6%.

Modest sample size (pilot study — n=22) but very significant p-value and real clinical effect magnitude. The Acar 2019 meta-analysis confirms the direction and magnitude across ~120 patients cumulated.

Study no. 6 in the HYX corpus. Proposed mechanism: H₂ penetrates neuronal membranes, neutralises •OH directly.


“We're not saying H₂ cures fibromyalgia. We're saying 22 patients saw their VAS drop. That's a difference.”

— Paul Fournier, Founder of HYDROGENYX

In numbers

  • −38% — VAS pain
  • n=22 RCT — Double-blind
  • p=0.002 — Highly significant

See the 7 studies →

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