The Source — the HYDROGENYX Journal
H2 vs ozone therapy — naturopathy comparison, two opposite logics
Paul Fournier
H2 or ozone? Two gas therapies, two opposing logics. Technical comparison for those interested in naturopathy without compromising on facts.
Two gases, two mechanisms
Ozone (O3) and molecular hydrogen (H2) are both used in naturopathy. Their mechanisms are diametrically opposed: ozone is a powerful oxidant (redox potential +2.07 V) that acts by generating controlled oxidative stress; H2 is a selective antioxidant (redox potential −0.42 V) that specifically neutralizes •OH and ONOO-.
Ozone therapy in brief
Principle
Medical administration of O3 at calibrated doses (autohemotherapy, rectal insufflation, ozonated water). Ozone induces transient oxidative stress that activates cellular repair pathways (Nrf2/ARE), upregulation of endogenous antioxidant enzymes (SOD, catalase, glutathione peroxidase). The expected benefit comes from hormesis – a small aggression that stimulates defense.
Framework
Regulated medical practice. In France, reserved for trained practitioners (DU ozonotherapy). Precise doses (μg/mL), certified equipment. Outside this framework: illegal and dangerous (pulmonary edema from pure inhalation).
Documented Indications
Herniated disc (Bocci 2011 review), chronic skin ulcers, moderate osteoarthritis. A body of clinical studies but heterogeneous, with variable methodologies.
Molecular hydrogen in brief
Principle
Oral consumption (enriched water, inhalation) of H2 at low doses (0.5 to 4 ppm). Mechanism: selective neutralization of the most toxic radicals (•OH, ONOO-) without affecting useful signaling radicals. No hormetic effect sought: the goal is to reduce net oxidative stress.
Framework
General public use. No documented toxic risk at doses used in beverages (LD50 ≈ 70% H2 in respiratory mixture, exceeding any possible consumption). No mandatory medical framework – it's a lifestyle supplement, like vitamin C.
Studied Indications
Sports recovery (Aoki 2012), metabolic syndrome (Nakao 2010), type 2 diabetes (Kajiyama 2008), inflammation (Song 2015). 320+ cumulative peer-reviewed studies, with no major contraindications.
Comparative Table
| Criterion | Ozone (O3) | Hydrogen (H2) |
|---|---|---|
| Mechanism | Pro-oxidant (hormesis) | Selective antioxidant |
| Framework | Strict medical | General public |
| Method | Injection / insufflation | Drinking / inhalation |
| Session cost | €60-120 | ≈ €0.30 (ELITE 9K cycle) |
| Toxicity | High outside framework | None documented |
| Cumulative studies | ≈ 400 RCTs (heterogeneous) | 320+ peer-reviewed |
Which to choose?
It's not a question of choosing one over the other. The two target different issues. Ozone is a temporary medical intervention for specific clinical situations. H2 is a daily hygiene routine. They are not mutually exclusive. For an ozone therapy approach, consult a trained doctor; to integrate H2 into your daily life, see our ELITE 9K.
To go further
Read the 7 key H2 studies 2026 or the comparison of dietary antioxidants vs H2.
HYDROGENYX · Paul Fournier sole trader · France · workshop Lyon 7e · 1 988 reviews 4.7/5 · 5-year warranty · 60-day money-back guarantee
HYDROGENYX Flask
The hydrogen ritual, ready in 5 minutes.
Up to ~9,000 ppb of dissolved molecular hydrogen (manufacturer's data), verifiable at home with a DPD test. 400 ml, touch screen, wireless charging base included.
60-day money-back guarantee · 5-year cell warranty · 4× Klarna
The HYDROGENYX Flask is a water preparation device, not a medical device. It does not prevent, treat, or cure any disease.
To go further: the science of hydrogen · the comparison · the FAQ
